Discover the top 5 must-visit destinations on a road trip from Buffalo, New York, to Port Charlotte, Florida. From Niagara Falls to Gasparilla Island, the journey is full of unforgettable experiences.

Planning a road trip from Buffalo, New York to Port Charlotte, Florida? Read our breakdown of routes, distances, and costs, including gas prices and tolls.

Planning a road trip from Buffalo, NY, to Port Charlotte, FL? Read on to know the fastest and alternative routes, distance, and driving time based on traffic and weather conditions.