Embark on an epic road trip from Buffalo, New York, to Newport, Tennessee, covering over 869-miles. Explore the top five must-visit destinations along the way, including Niagara Falls, Herschell Carrousel Factory Museum, Fallingwater, Gatlinburg, and Dollywood.

Planning a road trip from Buffalo, NY to Newport, TN? Check out our detailed guide on the cost of driving, including different routes, gas prices, and toll amounts.

Discover the best routes and places to stop along the way during a road trip from Buffalo, New York to Newport, Tennessee. Choose between the most direct, scenic, or adventurous route.