Discover five unexpected and unique places to stop on your road trip from Buffalo, New York, to Lexington, South Carolina. From breathtaking natural beauty to history and culture, this route has it all!

Planning a road trip from Buffalo, New York, to Lexington, South Carolina? We explore the different routes and provide a breakdown of gas costs, travel times, and distances to help you choose the most cost-effective option.

Discover the best routes and drive times for traveling from Buffalo, NY to Lexington, SC. Learn about tolls, traffic patterns, and scenic options for your journey.