Discover the top 5 attractions to visit on a road trip from Buffalo to Hilton Head Island. From the Luray Caverns to the Great Smoky Mountains, explore the best of the journey.

Plan your Buffalo, New York to Hilton Head Island, South Carolina road trip with estimated costs based on gas prices and tolls for three different routes.

Planning a road trip from Buffalo to Hilton Head Island? Check out our guide to the best routes and driving times to make your journey a success!