Discover the top five best places to visit on a road trip from Buffalo, NY to Frederick, MD. From historic towns to museums and nature spots, this journey has it all!

Planning a road trip from Buffalo, New York to Frederick, Maryland? Check out our guide to the different routes, distances, costs, and estimated time in driving to Frederick, Maryland based on current gas prices.

Discover the best routes for a road trip from Buffalo, NY to Frederick, MD. Explore scenic drives and charming small towns, and stop to enjoy local cuisine and attractions.