Embark on a road trip from Buffalo, New York to Daytona Beach, Florida and discover amazing museums, parks, and landmarks. Read our top 5 places to visit, including Niagara Falls, Great Smoky Mountains National Park, and more.

Planning a road trip from Buffalo, New York, to Daytona Beach, Florida? Check out this article for the cost and best routes based on current gas prices.

Embark on an epic road trip from Buffalo to Daytona Beach with our guide to the different routes and travel times. Discover charming towns, breathtaking views, and delightful attractions along the way.