Discover the top 5 must-visit destinations on a 650-mile road trip from Buffalo, NY to Charlotte, NC, including an organic architectural masterpiece, a waterfront area, and a world-renowned art museum. Explore charming towns and natural wonders along the way!

Planning a road trip from Buffalo to Charlotte? Check out these routes and their estimated driving times, distances, and costs based on current gas prices and toll fees. Safe travels!

Discover the fastest and slowest routes from Buffalo, New York to Charlotte, North Carolina, with driving time based on traffic patterns. Choose your preferred route and hit the road!