Discover the top five must-visit destinations on an epic East Coast road trip from Buffalo, NY to Avon Park, FL. Explore history in Colonial Williamsburg, relax on the beaches of Jekyll Island, and soak up the sun in Siesta Key.

Find out the cost and best routes for driving from Buffalo, New York to Avon Park, Florida based on current gas prices and toll fees. Plan ahead and budget for a fun road trip!

Discover the different routes to take between Buffalo, New York, and Avon Park, Florida. Get driving distances, times, and recommendations of places to stop along the way.