Discover the top five places to see between Bristol, Tennessee, and Sioux Falls, South Dakota. From Ruby Falls to Wall Drug Store, this road trip has it all. Don't miss out!

Planning a road trip from Bristol, TN to Sioux Falls, SD? Check out our breakdown of driving routes, distance, time, gas prices, and toll prices.

Drive from Bristol, TN to Sioux Falls, SD with scenic routes and recommended stops to add some adventure to your road trip. Read on for estimated drive times and tips.