Discover the top five must-visit stops on a road trip between Brandywine, Maryland, and Columbus, Ohio. From wildlife and architecture to history, music, and nature, this road trip has it all.

Planning a trip from Brandywine, Maryland to Columbus, Ohio? We break down the cost of different routes, including driving and flying, to help you save money.

Planning a road trip from Brandywine, Maryland to Columbus, Ohio? Read on for the fastest and slowest routes, distance, and time it takes based on traffic patterns.