Discover the top five most popular attractions to see on a trip between Boxborough, Massachusetts, and Hilton Head Island, South Carolina. Explore museums, historic sites, national parks, a famous mansion and iconic landmarks along the East Coast.

Planning a road trip from Boxborough, Massachusetts to Hilton Head Island, South Carolina? Read on for fuel cost breakdown and recommended routes. Choose the best one for your interests, timeframe, and budget.

This post explains the time it takes to drive from Boxborough, Massachusetts, to Hilton Head Island, South Carolina, highlighting the fastest and slowest routes, distance, traffic patterns, and drive times for each option.