Discover the top five must-see destinations on a road trip from Boston to Tupelo. From Acadia National Park to the Tupelo Visitor Center, make the most of your journey with our travel guide.

Find out the costs of driving from Boston to Tupelo with current gas prices and toll fees on four different routes. Get an estimated total gas cost and time.

Planning a road trip from Boston to Tupelo? Check out our guide for estimated driving times and distances for the fastest, scenic, quickest, and longest routes.