Take a scenic road trip from Boone, NC to Greenwood, SC, stopping at picturesque waterfalls, national parks, botanical gardens, and charming towns along the way. Discover the top places to see in this blog post.

Planning a trip from Boone, NC to Greenwood, SC? Read our breakdown of the three possible routes, with costs and distances for each, and our recommendation for the best route.

Discover the fastest and slowest routes to drive from Boone, North Carolina to Greenwood, South Carolina. Find out the distance and time it'll take based on traffic patterns during peak and off-peak hours.