Take a road trip from Bloomington, Indiana to Columbia, South Carolina, and experience the beauty of the Blue Ridge Parkway, the Gateway Arch, Mammoth Cave National Park, the Biltmore Estate, and Charleston. Read on for the top places to see on this unforgettable journey.

Planning a road trip from Bloomington, Indiana to Columbia, South Carolina? Check out our guide on the cost of driving there based on gas prices and different routes. Save money on your trip!

Discover the best and worst routes for driving from Bloomington, Indiana to Columbia, South Carolina. Learn about driving times based on traffic patterns and explore your travel options.