Discover the top five must-visit destinations on a road trip between Biloxi, Mississippi, and Cape Girardeau, Missouri, featuring historic sites, stunning landscapes, music, and more.

Planning a road trip from Biloxi to Cape Girardeau? Learn about the different routes, costs, distances, and times involved for your budget and schedule.

Learn the best routes to drive from Biloxi, Mississippi to Cape Girardeau, Missouri, and how long it takes to travel there based on traffic patterns. Check our detailed guide now!