Discover the top museums, parks, and landmarks to visit on a road trip from Barnstable, Massachusetts to Buffalo, New York. Journey through six states and explore exciting destinations such as the Museum of Science in Boston and Niagara Falls.

Planning a trip from Barnstable, Massachusetts to Buffalo, New York? Our guide breaks down the costs and different routes for a stress-free journey.

Planning a road trip from Barnstable to Buffalo? Discover the best routes, driving times, and must-see attractions along the way in this fun-filled travel guide.