Discover the top five must-visit destinations on a road trip from Baltimore, Maryland, to Buffalo, New York. Experience history, adventure, and breathtaking sights along the 400-mile route.

Compare the cost of driving from Baltimore to Buffalo by exploring three different routes and calculating gas prices, tolls, and travel time.

Planning a road trip from Baltimore to Buffalo? Check out our guide to the fastest and slowest routes, including travel times based on traffic patterns. Explore the options and enjoy the journey!