Discover the top five must-visit destinations on a road trip from Appleton, WI, to Monroe, LA. From iconic estates to interactive museums, explore unique attractions and meet new people along the way.

Planning a road trip from Appleton, Wisconsin to Monroe, Louisiana? Check out this article that breaks down the cost of gas, tolls, food, lodging, and activities for each route, and recommends the most direct route for an affordable and efficient journey.

Discover the best options for your long drive from Appleton, Wisconsin to Monroe, Louisiana. Read our article for recommended routes and places to stop along the way.