Get ready to hit the open road and explore the top destinations on your trip from Appleton, Wisconsin, to Charlotte, North Carolina. Discover the best the Midwest and the South have to offer with our road trip guide!

Planning a road trip from Appleton, Wisconsin to Charlotte, North Carolina? Check out this post for estimated costs of gas and tolls for different routes based on current gas prices.

Planning a road trip from Appleton, WI, to Charlotte, NC? Check out our blog post for the fastest and slowest routes and calculate the driving time based on traffic patterns.