Discover the top five places to visit on a road trip from Annapolis, Maryland to Knoxville, Tennessee. From historic Williamsburg to stunning Great Smoky Mountains National Park, this trip has it all.

Discover the cost of driving from Annapolis, Maryland to Knoxville, Tennessee, based on current gas prices. Get details on the best routes, distance, and time, including toll prices. Plan your trip now!

Planning a road trip from Annapolis, MD to Knoxville, TN? Check out our guide to the fastest and slowest routes, distance, and driving time based on traffic patterns.