Embark on a road trip from Anna, Illinois to Sioux Falls, South Dakota and discover the Heartland of America. Here are the Top Places to See on this adventure!

This post outlines three different routes for driving from Anna, Illinois to Sioux Falls, South Dakota and estimates the total cost for gas, not including toll expenses.

Planning a road trip from Anna, Illinois to Sioux Falls, South Dakota? Read our guide to the fastest and most scenic routes, drive times, and peak traffic patterns to make your journey smooth and enjoyable.