Discover the top places to visit on a road trip from Anna Maria Island, FL, to Santee, SC. Explore charming towns, gorgeous beaches, historic sites, and natural beauty.

Planning a road trip from Anna Maria Island, Florida, to Santee, South Carolina? Learn about the 3 routes available, the distance, cost, and time it takes per route based on the current gas prices.

Planning a road trip from Anna Maria Island, FL to Santee, SC? Learn about the fastest and slowest routes, traffic patterns, and estimated drive times in our ultimate guide.