Discover the top places to see when driving from Anderson, South Carolina, to Indianapolis, Indiana. Explore scenic mountains, national parks, iconic landmarks, and kid-friendly attractions along the way.

Planning a road trip from Anderson, South Carolina to Indianapolis, Indiana? Check out the cost of each route based on current gas prices and toll fees in this helpful guide.

Planning a road trip from Anderson, SC to Indianapolis, IN? Check out the fastest and slowest routes and estimated driving times in this guide.