Discover the top places to visit when driving from Anderson, Indiana to Myrtle Beach, South Carolina. From historic Charleston to the scenic Smoky Mountains, this road trip has it all.

Planning a road trip from Anderson, Indiana to Myrtle Beach, South Carolina? Check out the cost of gas and tolls for the fastest, most scenic, and coastline routes.

Planning a road trip from Anderson, Indiana to Myrtle Beach, South Carolina? Our post covers the fastest, slowest, and most scenic routes with estimated driving times based on traffic patterns.