Discover the best things to do on a road trip from Amesbury, Massachusetts to Syracuse, New York. Explore historic villages, scenic mountains, iconic museums, and stunning state parks on this 300-mile journey.

Plan your trip from Amesbury to Syracuse with our guide to the different routes available, including estimated fuel and toll costs. Choose the best route for your budget and schedule.

Planning to drive from Amesbury, Massachusetts to Syracuse, New York? Get all the information you need about the fastest and slowest routes, distance, and driving time based on traffic patterns in this comprehensive guide.