Embark on an epic road trip from Ames, Iowa to La Mesa, California. Discover the top places to see along the way, from the Great Plains to the desert Southwest.

Discover the cost of driving from Ames, Iowa, to La Mesa, California, based on current gas prices. Explore different routes, their distance, time, and toll cost in this friendly guide.

Planning a road trip from Ames, Iowa to La Mesa, California? Read on to find out the fastest and scenic routes, distance, driving times during peak and leisure hours, and tips on how to enjoy the journey.