Discover the top attractions to see when driving from Amarillo, Texas to Effingham, Illinois. Explore Cadillac Ranch, Palo Duro Canyon, Route 66, Gateway Arch National Park, and more.

Planning a road trip from Amarillo, Texas to Effingham, Illinois? Check out the cost breakdown based on current gas and toll prices for each route before you hit the road!

Discover the fastest and scenic routes to travel from Amarillo to Effingham. Learn the distance and time it takes based on traffic patterns in this guide.