Explore the top places to see on a road trip from Affton, Missouri to Saint Charles, Missouri. Discover the Gateway Arch, Missouri Botanical Garden, Katy Trail State Park, historic Main Street in St. Charles, and Missouri wine country.

Planning a road trip from Affton to Saint Charles but unsure of the cost? Read on to discover the estimated cost of three different routes, including gas prices and toll fees.

Plan your next road trip from Affton to Saint Charles, Missouri with our guide. Discover the fastest and slowest routes, distance, and driving time based on traffic patterns.